Table 1 EGIL classification scheme
From: An ontology for representing hematologic malignancies: the cancer cell ontology
EGIL classification system | |
|---|---|
Immunologic subgroup | Immunophenotypic profile |
B-lineage ALL | CD19+ and/or CD79a + and/or CD22+ |
B-I (pro-B) | No B-cell differentiation antigens |
B-II (common B) | CD10+ |
B-III (pre-B) | cyIgμ+ |
B-IV (mature B) | cylg or sIg λ + or κ+ |
T-lineage ALL | Cytoplasmic/surface CD3+ |
T-I (pro-T) | CD7+ |
T-II (pre-T) | CD2+ and/or CD5+ and/or CDS+ |
T-III (cortical T) | CD1a+ |
T-IV (mature T) | Surface CD3+, CD la- |
α/β (group a) | TCR α/β+ |
γ/δ (group b) | TCR γ/δ+ |
Early myeloid (AML-MO) | MPO ± but enzymatic MPO−/CD13+/CD33+/ CD65+/and-or CD 117+ |
Myelo/monocytic lineage | MPO+/CD13+/CD33+/CD65+/and-or CD117+ |
Megakaryocytic lineage | CD41+ and/or CD61+ (surface or cytoplasmic) |
Erythroid lineage | Early/immature: unclassified by markers Late/mature: GPA+ |
Undifferentiated | Often CD34+/HLA-DR+/CD38+/CD7+ |