TY - JOUR AU - Luo, Min AU - Jiao, Jianfeng AU - Wang, Ruiqi PY - 2019 DA - 2019/05/01 TI - Screening drug target combinations in disease-related molecular networks JO - BMC Bioinformatics SP - 198 VL - 20 IS - 7 AB - For treating a complex disease such as cancer, some effective means are needed to control biological networks that underlies the disease. The one-target one-drug paradigm has been the dominating drug discovery approach in the past decades. Compared to single target-based drugs, combination drug targets may overcome many limitations of single drug target and achieve a more effective and safer control of the disease. Most of existing combination drug targets are developed based on clinical experience or text-and-trial strategy, which cannot provide theoretical guidelines for designing and screening effective drug combinations. Therefore, systematic identification of multiple drug targets and optimal intervention strategy needs to be developed. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-019-2730-8 DO - 10.1186/s12859-019-2730-8 ID - Luo2019 ER -