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Table 2 Description and symbols of synergism or antagonism in drug target combination studies analyzed with the CI method

From: Screening drug target combinations in disease-related molecular networks

Range of Combination Index

Description

Graded Symbols

<0.1

very strong synergism

+ + + + +

0.1-0.3

strong synergism

+ + + +

0.3-0.7

synergism

+ + +

0.7-0.85

moderate synergism

+ +

0.85-0.90

slight synergism

+

0.90-1.10

nearly additive

+ -

1.10-1.20

slight antagonism

-

1.20-1.45

moderate antagonism

- -

1.45-3.3

antagonism

- - -

3.3-10

strong antagonism

- - - -

>10

very strong antagonism

- - - - -