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Table 2 Description and symbols of synergism or antagonism in drug target combination studies analyzed with the CI method

From: Screening drug target combinations in disease-related molecular networks

Range of Combination Index Description Graded Symbols
<0.1 very strong synergism + + + + +
0.1-0.3 strong synergism + + + +
0.3-0.7 synergism + + +
0.7-0.85 moderate synergism + +
0.85-0.90 slight synergism +
0.90-1.10 nearly additive + -
1.10-1.20 slight antagonism -
1.20-1.45 moderate antagonism - -
1.45-3.3 antagonism - - -
3.3-10 strong antagonism - - - -
>10 very strong antagonism - - - - -