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Table 1 Partial inference results of the significant TFs/motifs in the exploration of EPA&DHA dietary effects

From: The cis-trans binding strength defined by motif frequencies facilitates statistical inference of transcriptional regulation

TFs Motifs P-values, upside** P-values, downside** Regulation* Functions
PPARα V$PPARA_01 0.00010 0.55 Attenuate hyperlipidemia [24]
Enhance insulin sensitivity [35, 36]
Promote fatty acid metabolism [37]
Regulate adipogenesis [19, 20]
V$PPARDR1_Q2 0.00030 0.37
PPARγ V$PPARG_01 < 0.00010 0.22
V$PPARG_02 0.00010 0.17
C/EBPs V$CEBP_C 0.0049 0.69 Induce adipogenesis [21,22,23]
V$CEBPA_Q6 0.0058 0.57
V$CEBPB_02 0.0039 0.66
V$CEBPD_Q6_01 0.0043 0.74
V$CEBPE_01 0.0006 0.97
V$CEBPG_Q6 0.0019 0.47
NF-κB V$NFKB_C 0.73 0.0039 Reduce inflammation [38]
V$NFKB_Q6 0.33 0.0033
Stats V$STAT1_Q6 0.011 0.27
V$STAT4_Q5 < 0.00010 0.26
V$STAT5A_02 0.0074 0.30
Ets family V$ETS2_Q6 0.91 0.011 Inhibit angiogenesis [27, 28]
V$PEA3_01 0.33 0.0050
V$CETS1_01 0.40 0.0066
V$CETS2_02 0.46 0.036
V$ELF_02 0.17 0.0098
V$ELF4_02 0.17 0.0047
V$ELF5_03 0.76 0.011
V$ERF_01 0.43 0.0269
V$ERF_02 0.14 0.0084
V$ETV3_01 0.17 0.0083
Rora V$RORA_Q4 0.0035 0.34 Enhance circadian rhythm [30, 31]
V$RORA2_01 0.00020 0.89
Dbp V$DBP_Q6_01 0.015 0.98
SP1 V$SP1_01 0.37 0.0099
Ahr V$AHR_01 0.058 0.0082
Arnt V$ARNT_01 0.23 0.013 Reduce hypoxia [29]
  1. * ↑↓: The TF/motif was up/down-regulated in modified BASE.
  2. ** Tests with the up/down-regualted genes, 10,000 permutations.