Table 1 Partial inference results of the significant TFs/motifs in the exploration of EPA&DHA dietary effects

PPARα

V$PPARA_01

0.00010

0.55

↑

Attenuate hyperlipidemia ^[24]

Enhance insulin sensitivity ^{[35, 36]}

Promote fatty acid metabolism ^[37]

Regulate adipogenesis ^{[19, 20]}

V$PPARDR1_Q2

0.00030

0.37

PPARγ

V$PPARG_01

< 0.00010

0.22

↑

V$PPARG_02

0.00010

0.17

C/EBPs

V$CEBP_C

0.0049

0.69

↑

Induce adipogenesis ^[21,22,23]

V$CEBPA_Q6

0.0058

0.57

V$CEBPB_02

0.0039

0.66

V$CEBPD_Q6_01

0.0043

0.74

V$CEBPE_01

0.0006

0.97

V$CEBPG_Q6

0.0019

0.47

NF-κB

V$NFKB_C

0.73

0.0039

↓

Reduce inflammation ^[38]

V$NFKB_Q6

0.33

0.0033

Stats

V$STAT1_Q6

0.011

0.27

↑

V$STAT4_Q5

< 0.00010

0.26

V$STAT5A_02

0.0074

0.30

Ets family

V$ETS2_Q6

0.91

0.011

↓

Inhibit angiogenesis ^{[27, 28]}

V$PEA3_01

0.33

0.0050

V$CETS1_01

0.40

0.0066

V$CETS2_02

0.46

0.036

V$ELF_02

0.17

0.0098

V$ELF4_02

0.17

0.0047

V$ELF5_03

0.76

0.011

V$ERF_01

0.43

0.0269

V$ERF_02

0.14

0.0084

V$ETV3_01

0.17

0.0083

Rora

V$RORA_Q4

0.0035

0.34

↑

Enhance circadian rhythm ^{[30, 31]}

V$RORA2_01

0.00020

0.89

Dbp

V$DBP_Q6_01

0.015

0.98

↑

SP1

V$SP1_01

0.37

0.0099

↓

–

Ahr

V$AHR_01

0.058

0.0082

↓

–

Arnt

V$ARNT_01

0.23

0.013

↓

Reduce hypoxia ^[29]