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Table 2 Partial conclusions from the inference of TFs regulation were verified by gene functional enrichment analysis

From: The cis-trans binding strength defined by motif frequencies facilitates statistical inference of transcriptional regulation

Conclusions Pathways P-values, upside* P-values, downside* Regulation
Enhance insulin sensitivity
Promote adipogenesis
Attenuate hyperlipidemia
PPAR signaling pathway (KEGG) 3.98e-8 ≈1
Peroxisome (KEGG) 4.62e-11 ≈1
peroxisome organization 2.99e-4 ≈1
Promote fatty acid metabolism fatty acid metabolism (KEGG) 1.86e-9 ≈1
cellular lipid metabolic process (GO) 3.49e-7 ≈1
long-chain fatty acid metabolic process (GO) 9.54e-6 ≈1
very long-chain fatty acid metabolic process (GO) 6.73e-5 ≈1
regulation of fatty acid oxidation (GO) 5.30e-4 ≈1
fatty acid beta-oxidation (GO) 1.17e-5 ≈1
Inhibit angiogenesis blood vessel development (GO) 0.996 3.72e-3
Reduce inflammation intestinal immune network for IgA production (KEGG) 0.995 5.32e-3
  1. * Gene functional enrichemnt in the up/down-side with Wilcox rank sum test, see Method.