Fig. 2

Multiple mechanisms contribute to dysregulation of lipid metabolism genes in cancer. a Pearson correlation estimation (p < 0.05) of the association between mRNA expression and DNA methylation in the promoter region across pan-cancer. b Gene mutation versus its mRNA expression (red color represents there is significant (wilcox test, p < 0.05) difference of the mRNA expression between the mutated group and the non-mutated group, while grey color represents that no significant difference observed between the mutated group and the non-mutated group. To perform statistic testing, the number of samples in either the mutated group or the non-mutated group should be greater or equal to three. The white color represents the gene is with less than three mutated samples.). c Transcription factor mutation versus targets expression (Color as the same as B). d Pearson correlation estimates of association between the expression of transcript factors and their target genes across pan-cancer. The circle size is proportional to the significance level of correlation results