Fig. 5

Distribution of AUC of gene-clustering using “incomplete” annotations. Panel (a) plots AUC of clustering using cellular process annotation set, and panel (b) plots AUC of clustering using multicellular organism process annotation set. HAG and DAG represent hierarchical clustering and Directed Acyclic Graph (CliXO) clustering, respectively. MAX, BMA and AVG represent the maximal functional similarity, the average of best-matched functional similarities, and the average of all functional similarities among genes, respectively. Combinations were ordered by the median AUC value. The red line represents the median AUC value across all combinations. An asterisk above a boxplot indicates that the AUC of the corresponding combination is significantly lower than the best (the combination with highest median AUC). The significance is determined by one-directional paired t test, P < 0.05