Fig. 6

Plots of the robustness to annotation incompleteness for semantic similarity methods, for different similarity measures using hierarchical clustering. Points with filled circles show robustness of multicellular process annotation sets; lines without points show robustness of cellular process annotation sets. In red is the fraction of genes originally clustered together using complete annotations, that remained in the best-matched cluster using incomplete annotations. In blue is the fraction of singletons (unclustered genes) originally derived using complete annotations, that remained as singletons using incomplete annotations. A total of 10 different clustering thresholds increase from the left to the right evenly, based on the height of corresponding hierarchical tree from the leaves (0) to the root (1)