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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies

Fig. 1

Overview of Computational Approach. The R package limma was used to find differentially expressed genes (left square). Metabolic Adjustment for Differential Expression (MADE) algorithm was used to produce the condition-specific models (right 3 circles). Flux balance analysis (FBA) and simulated reaction deletions predicted drug targets for chloroquine-treated parasites. CQ = Chloroquine

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