Fig. 2
From: Metabopolis: scalable network layout for biological pathway diagrams in urban map style
An example of major pathways in human metabolism, including eleven categories highlighted in differently colored blocks. The red route indicates a path for cytoplasmatic oxidation of glucose in cytoplasm in order to obtain ATP (energy), and the blue route shows how humans transform ammonia to urea to eliminate the toxic ammonia in the Urea Cycle. Our visualization shows that the first procedure only occurs in Glycolysis Gluconeogenesis (orange block) locally, while the chemical components globally move across multiple categories (e.g., mitochondria to cytoplasm through the transport pathways) in the second process. The green route further highlights how the energy generated from the glucose oxidation comes to support catalyzing the urea synthesis. Users can simultaneously read the local and global information using the diagram generated by our system