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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Detailed prediction of protein sub-nuclear localization

Fig. 5

Odds ratio of protein-protein interactions (PPIs) in the human nuclear proteome. The heatmap shows the odds ratio of PPIs within and between 13 sub-nuclear compartments. The experimentally annotated PPIs were extracted from mentha [46], the Integrated Interactions Database (iid) [47], the Human Reference Protein Interactome Mapping Project (HuRI) [48] (data gathered by the Center for Cancer Systems Biology at the Dana-Farber Cancer Institute and supported by the National Human Genome Research Institute of NIH, the Ellison Foundation, Boston, MA and the Dana-Farber Cancer Institute Strategic Initiative, accessed on 14-02-2018), HINT [49], iRefIndex [50], InBio Map [51] and mapped to those in human proteins of 13 predicted sub-nuclear compartments. Values below 1 (depicted by green colors) indicate less PPIs between proteins in these compartments than expected, values equal to 0 (depicted by white) indicate as many PPIs as expected and values above 1 (depicted by red colors) indicate more PPIs than expected. PPIs are observed more often than expected within all compartments and also between proteins in the Spindle apparatus and Kinetochore as well as proteins in the Nuclear Pore Complex, Nuclear Lamina and Nuclear Envelope which can be explained by the shared functionality of the different compartments

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