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Table 2 Comparison between LocNuclei and NSort

From: Detailed prediction of protein sub-nuclear localization

Sub-nuclear compartmentNumber of proteinsAUC NSortAUC LocNuclei-NSort
Perinucleolar240.80 ± 0.050.73 ± 0.03
Cajal body490.60 ± 0.030.62 ± 0.02
Nuclear pore complex510.79 ± 0.050.88 ± 0.02
Nuclear lamina770.70 ± 0.010.82 ± 0.01
PML bodies910.77 ± 0.030.75 ± 0.01
Chromatin3230.71 ± 0.010.78 ± 0.01
Nuclear speckle4030.71 ± 0.010.77 ± 0.01
Nucleolus5980.60 ± 0.010.72 ± 0.01
Sum/Mean12850.71 ± 0.030.76 ± 0.02
  1. For this comparison, LocNuclei was re-trained using the development data of NSort, comprising 1285 sequence-unique proteins annotated in eight sub-nuclear localization classes. On proteins from all eight classes, LocNuclei performed equally well as or better than NSort except for proteins located in the perinucleolar. The overall cross-validated AUC of LocNuclei was 0.76 compared to 0.71 for NSort. The values for NSort were taken from its publication [12]