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Table 8 p-values obtained by 1-sided Fisher’s and Barnard’s tests on the CASP dataset for head-to-head comparison of the algorithms on lowest energy and average energy of the best 10 decoys (a), lowest lRMSD and average lRMSD of the best 10 decoys (b), highest TM-score and average TM-score of the best 10 decoys (c), and highest GDT_TS score and average GDT_TS score of the best 10 decoys (d)

From: Balancing multiple objectives in conformation sampling to control decoy diversity in template-free protein structure prediction

(a)

Test

Lowest energy

Avg. energy of the best 10

 

Fisher’s

0.08945

0.01151

 

Barnard’s

0.05789

0.005909

(b)

Test

Lowest lRMSD

Avg. lRMSD of the best 10

 

Fisher’s

0.3281

0.002739

 

Barnard’s

0.2617

0.001288

(c)

Test

Highest TM-score

Avg. TM-score of the best 10

 

Fisher’s

0.6719

0.5

 

Barnard’s

0.9991

0.4119

(d)

Test

Highest GDT_TS score

Avg. GDT_TS score of the best 10

 

Fisher’s

0.5

0.5

 

Barnard’s

0.4119

0.4119

  1. All tests evaluate the null hypothesis that Evo-Diverse does not perform better than Rosetta, p-values less than 0.05 are marked in bold