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Table 3 Run time of pwrEWAS for different combinations of sample sizes and effect sizes

From: pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS)

Total sample sizes

Effect sizes (Δβ)

0.1

0.1, 0.2

0.1, 0.3, 0.5

10

2 min 21 s

3 min 11 s

3 min 50s

100

6 min 22 s

7 min 39 s

8 min 33 s

500

24 min 43 s

27 min 36 s

29 min 22 s

10–100 (increments of 10)

9 min 40s

16 min 34 s

23 min 44 s

300–500 (increments of 100)

27 min 58 s

30 min 01 s

52 min 00s

  1. In all scenarios presented the number of tested CpGs was assumed to be 100,000, number of simulated data sets was 50, and the method to perform the differential methylation analysis as limma. A total of 6 clusters/threads were used