Skip to main content

Table 1 Table summarizes the top 10 most sensitive system parameters for the global sensitivity analysis concerning integrated β-casein (left), transcription time delay (middle) and time-dependent switch (right). For each output parameter, some of the hypothesized mechanisms are highlighted. For example, for transcription time delay the mRNA and STAT transport rates are in bold

From: Time-dependent antagonist-agonist switching in receptor tyrosine kinase-mediated signaling

Casein (JAK-independent in bold) Delay (Transport Reactions in Bold) Ratio (Heterodimerization reactions in bold)
Parameter Name Parameter Name Parameter Name
n_transc Transcription Hill Coefficient kR45 mRNA Nuclear Export Casein kfR41 HER4 Heterodimerization
V_transc Transcription Half-Maximum rate kR25 Translation kR39 STATc Phosphorylation JAK independent
kR46 mRNA degradation rate kR20 Nuclear STAT dimer dephosphorylation kfR36 IFNR (HER4 s80) Formation
kR20 Nuclear STAT dimer dephosphorylation kR46 mRNA degradation rate kfR01 HER4 JAK Binding
kR39 STATc Phosphorylation JAK independent kR15 STAT Dimer Nuclear Translocation kR37 IFNR (HER4 s80) Activation
kfR41 HER4 Heterodimerization kR24 mRNA Nuclear Export kfR42 HER4 Heterodimerization Constitutive
kfR36 IFNR (HER4 s80) Formation kfR29 STATc SOCS HER4 JAK SHP Binding kfR43 HER4 Heterodimer Ligand Binding
kR37 IFNR (HER4 s80) Activation SOCS_Binding_Rate SOCS Mediated negative feedback kR06 STATc Phosphorylation JAK Dependent
kfR19 Nuclear STAT Dimer PPN Binding kfR19 Nuclear STAT Dimer PPN Binding kR25 Translation
K_transc Transcription Equilibrium Coefficient kfR43 HER4 Heterodimer Ligand Binding SOCS_Binding_Rate SOCS Mediated negative feedback