From: Time-dependent antagonist-agonist switching in receptor tyrosine kinase-mediated signaling
Casein (JAK-independent in bold) | Delay (Transport Reactions in Bold) | Ratio (Heterodimerization reactions in bold) | |||
---|---|---|---|---|---|
Parameter | Name | Parameter | Name | Parameter | Name |
n_transc | Transcription Hill Coefficient | kR45 | mRNA Nuclear Export Casein | kfR41 | HER4 Heterodimerization |
V_transc | Transcription Half-Maximum rate | kR25 | Translation | kR39 | STATc Phosphorylation JAK independent |
kR46 | mRNA degradation rate | kR20 | Nuclear STAT dimer dephosphorylation | kfR36 | IFNR (HER4 s80) Formation |
kR20 | Nuclear STAT dimer dephosphorylation | kR46 | mRNA degradation rate | kfR01 | HER4 JAK Binding |
kR39 | STATc Phosphorylation JAK independent | kR15 | STAT Dimer Nuclear Translocation | kR37 | IFNR (HER4 s80) Activation |
kfR41 | HER4 Heterodimerization | kR24 | mRNA Nuclear Export | kfR42 | HER4 Heterodimerization Constitutive |
kfR36 | IFNR (HER4 s80) Formation | kfR29 | STATc SOCS HER4 JAK SHP Binding | kfR43 | HER4 Heterodimer Ligand Binding |
kR37 | IFNR (HER4 s80) Activation | SOCS_Binding_Rate | SOCS Mediated negative feedback | kR06 | STATc Phosphorylation JAK Dependent |
kfR19 | Nuclear STAT Dimer PPN Binding | kfR19 | Nuclear STAT Dimer PPN Binding | kR25 | Translation |
K_transc | Transcription Equilibrium Coefficient | kfR43 | HER4 Heterodimer Ligand Binding | SOCS_Binding_Rate | SOCS Mediated negative feedback |