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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development

Fig. 1

Reconstruction of the ovarian follicle metabolic model, OvoFol Recon 1, based on transcriptomic data. a Follicle sizes and age of the mice that the follicles were collected from; b Heatmap of the top significantly expressed genes for each follicle stage and follicle cell type; c Bi-partite graph of the Mice Recon 2 metabolic model, showing enzymes in purple and metabolites in green; d Bi-partite graph of OvoFol Recon 1 metabolic model constructed using FASTCORE from Mouse Recon 2. PND, post-natal day; PMSG, pregnant mare serum gonadotropin; PREANTRAL, pre-antral follicles between 200 and 300 μm; ANTRAL, antral follicles, between 400 and 600 μm; PMD, primordial; PR, primary; 2LS, two layered secondary; MLS, multi-layer secondary; SC, secondary follicle; SA, small antral; LA, large antral; CC, cumulus cells; MR, mural cells; CCTR, cumulus granulosa cells in large antral follicles during the acquisition of oocyte competence; NSN, non-surrounded oocyte nucleolus; SN, surrounded oocyte nucleolus

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BMC Bioinformatics

ISSN: 1471-2105

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