Fig. 5

The correspondence between genes identified as associated with Type II Diabetes in different populations and their role in T2D subtypes. The top panel shows the distribution of the genes that are found to be associated with T2D in each population with respect to their association with two common T2D subtypes. For each population, among the genes that are found to be associated with T2D in that population, yellow bars represent the number of genes that are associated with Insulin Secretion Deficiency, red bars represent the number of genes associated with Insulin Resistance subtype and the orange bars represent the number of genes that are associated with both subtypes. The bottom panel shows the corresponding distribution for network-based overlap, where a gene is considered to be identified in a population if it is in the most significant subnetwork identified by network analysis on that population. The color codes used in the right panel are identical to that in the left panel. The rightmost bar shows the number of all other T2D genes that were identified in at least one population, color-coded for the population