Fig. 2
From: In silico modeling of phosphorylation dependent and independent c-Myc degradation
Schematic representation of two models. a A schematic representation of Model 1; b A schematic representation of Model 2. A: Model 1 (phosphorylation dependent degradation) showing all four states of c-Myc along with the PTMs associated. It also shows the rate constants involved in this model. (GF stands for Growth Factors) B: Model 2 (phosphorylation independent) showing the two states of c-Myc along Skp2. It also shows the rate constants involved in this model. Arrow legends: green lines show conversions between states of Myc, dotted lines show binding reactions, solid lines represent kinetic reactions. For the values and equations of the rate constants, refer to Methods section