Table 5 Cociter analysis of top 30 lung cancer driver genes identified by our method
Genes | Driver | Lung | Cancer | Is_driver | Ours | Diffusion | Muf_max | Muf_sum | IntDriver | Driver Net | Dawn Rank |
|---|---|---|---|---|---|---|---|---|---|---|---|
TP53 | 110 | 999 | 6772 | 1 | 1 | 36 | 5 | 12 | 5 | 1 | 1 |
TTN | 2 | 1 | 10 | 1 | 2 | 2274 | 2 | 13 | 2 | 15 | 156 |
KRAS | 172 | 1217 | 3525 | 1 | 3 | 20 | 102 | 15 | 19 | 3 | 2 |
RYR2 | 2 | 4 | 3 | 0 | 4 | 681 | 101 | 16 | 11 | 21 | 493 |
MUC16 | 1 | 31 | 338 | 1 | 5 | 1587 | NA | NA | 3 | 16 | 507 |
UBC | 2 | 17 | 134 | 0 | 6 | 4 | 100 | 1 | NA | 2 | NA |
EGFR | 166 | 2849 | 4748 | 1 | 7 | 2 | 7 | 22 | 168 | 4 | 4 |
SPTA1 | 1 | 2 | 3 | 0 | 8 | 140 | NA | NA | 24 | 5 | 13 |
LRP1B | 2 | 8 | 17 | 1 | 9 | 5321 | NA | 18 | 8 | 482 | 1508 |
DMD | 3 | 17 | 23 | 0 | 10 | 164 | 3 | 31 | 157 | 74 | 9 |
STK11 | 8 | 160 | 504 | 1 | 11 | 205 | NA | 34 | 70 | 31 | 14 |
MUC17 | 0 | 0 | 9 | 0 | 12 | 484 | NA | NA | 13 | 161 | 791 |
ANK2 | 0 | 1 | 4 | 0 | 13 | 160 | NA | NA | 80 | 62 | 6 |
PIK3CA | 54 | 183 | 1199 | 1 | 14 | 3 | NA | 56 | NA | 6 | 109 |
ACTN2 | 1 | 3 | 7 | 0 | 15 | 27 | 9 | 40 | NA | 77 | 20 |
FAT3 | 1 | 2 | 1 | 0 | 16 | 330 | NA | NA | 48 | 89 | 224 |
COL11A1 | 1 | 9 | 21 | 1 | 17 | 215 | NA | 30 | 16 | 12 | 18 |
PCLO | 1 | 0 | 4 | 0 | 18 | 5326 | NA | NA | 36 | 851 | 2664 |
PLCG2 | 1 | 2 | 13 | 0 | 19 | 10 | NA | 137 | NA | 34 | NA |
NF1 | 11 | 16 | 165 | 1 | 20 | 40 | NA | 108 | 129 | 19 | 22 |
PRKCB | 1 | 11 | 41 | 1 | 21 | 6 | NA | 60 | NA | 17 | NA |
PCDH15 | 1 | 2 | 4 | 0 | 22 | 227 | NA | 19 | 31 | 11 | 98 |
STAT3 | 27 | 418 | 1824 | 0 | 23 | 7 | 97 | 45 | NA | 20 | 35 |
CREBBP | 2 | 15 | 117 | 0 | 24 | 1 | 38 | 110 | NA | 10 | 112 |
PLCB1 | 1 | 7 | 9 | 0 | 25 | 24 | NA | 52 | 192 | 24 | 26 |
MYH2 | 1 | 4 | 3 | 0 | 26 | 55 | NA | 49 | 108 | 14 | 27 |
ATM | 5 | 139 | 1377 | 1 | 27 | 133 | 12 | 144 | NA | 27 | 417 |
MYH8 | 1 | 0 | 0 | 0 | 28 | 291 | 8 | 81 | NA | 1157 | 804 |
ZNF536 | 1 | 0 | 4 | 1 | 29 | 1907 | NA | NA | 25 | 1039 | 1458 |
APOB | 2 | 4 | 27 | 0 | 30 | 480 | NA | 25 | 15 | 43 | 21 |