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Table 2 Proportion of realizations with p < 0.05 for ES, ESavg, and < ESavg > for 25 splits. The proportion was calculated over 100 realizations of the dataset for each of the 21 gene sets using the 3 test statistics, ES, ESavg, and < ESavg > with M = 25. a indicates a control gene set with no association with phenotype

From: Improving the power of gene set enrichment analyses

Gene Set

Proportion with p < 0.05

ES

ESavg

<ESavg>

a a

0.06

0.08

0.05

b

1.00

1.00

1.00

c

0.82

0.81

0.92

d

0.09

0.09

0.14

e

0.38

0.39

0.46

f

0.06

0.13

0.10

g

0.01

0.00

0.01

h

0.29

0.19

0.19

i

0.10

0.16

0.07

j a

0.07

0.07

0.07

k

0.92

0.93

0.98

l

0.81

0.88

0.91

m

0.92

0.94

0.98

n

0.34

0.35

0.43

o

0.73

0.76

0.84

p

0.42

0.56

0.64

q

0.77

0.84

0.90

r

0.22

0.26

0.22

s

0.75

0.77

0.90

t

0.36

0.38

0.44

u

0.25

0.28

0.37