TY - JOUR AU - Feuerbach, Lars AU - Sieverling, Lina AU - Deeg, Katharina I. AU - Ginsbach, Philip AU - Hutter, Barbara AU - Buchhalter, Ivo AU - Northcott, Paul A. AU - Mughal, Sadaf S. AU - Chudasama, Priya AU - Glimm, Hanno AU - Scholl, Claudia AU - Lichter, Peter AU - Fröhling, Stefan AU - Pfister, Stefan M. AU - Jones, David T. W. AU - Rippe, Karsten AU - Brors, Benedikt PY - 2019 DA - 2019/05/28 TI - TelomereHunter – in silico estimation of telomere content and composition from cancer genomes JO - BMC Bioinformatics SP - 272 VL - 20 IS - 1 AB - Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrations in telomere composition. To retrieve these telomere characteristics from high-throughput sequencing data the available computational approaches need to be extended and optimized to fully exploit the information provided by large scale cancer genome data sets. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-019-2851-0 DO - 10.1186/s12859-019-2851-0 ID - Feuerbach2019 ER -