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Table 1 Comparing deregulated complexes of JDACO, CORUM and hu.MAP

From: Differential analysis of combinatorial protein complexes with CompleXChange

Results sets compared

Exact matches

Average overlap

Reasonable overlap [%]

CORUM / JDACO

0

0.24±0.12

32.5

hu.MAP / JDACO

0

0.17±0.16

18.8

hu.MAP / CORUM

1

0.08±0.24

6.3

hu.MAP (all) / CORUM (all)

5

0.12±0.19

11.9

  1. “hu.MAP (all)” and “CORUM (all)” depict the sets of all TFCs in the respective datasets whereas all other sets cover the reported deregulated complexes. Overlap between two protein complexes was quantified using the overlap score ω [66], “average overlap” between two result sets means the average of all best matches in terms of ω between the first (smaller) and second (larger) set of reported deregulated protein complexes. The percentage of complexes in the first (smaller) set with any reasonable match (ω>0.25, as in [26, 67, 68]) in the second (larger) set is termed “reasonable overlap”