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Table 3 Traits and validation of the recommended drugs

From: Drug repurposing with network reinforcement

Drug

(Compound)

Amantadine

Conotoxin GV

Tenocyclidine

Cycloleucine

Remarks for validation

Bioactivity/Medication: Amantadine can be used as an anti-parkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia.

Enhanced Network:

Conotoxin GV is known to act on N-methyl D-aspartate acid receptor (NMDA receptor)

Sharing target protein:

Tenocyclidine share four target proteins with memantine: Alpha-7 nicotinic cholinergic receptor subunit, Glutamate receptor ionotropic, NMDA 2A / 2B / 3A

Sharing target protein:

Cycloeucine share one target protein with memantine: Glutamate receptor ionotropic, NMD1;

PMID10051153, 7,773,540