Fig. 4

Node overlap between the three pathway representations of mTOR signaling. Note that this analysis includes all modalities harmonized by PathMe (e.g., genes, metabolites, miRNAs, biological processes). Particularly for mTOR signaling, while there are overlapping nodes between each pair of databases and between all three, each database also contributes unique nodes to the consolidated mTOR signaling network, providing a more comprehensive overview of mTOR signaling. In a), a more detailed analysis conducted on IPython notebooks shows the proportion of shared nodes across the three equivalent representations. Equivalent interactive Venn diagrams can also be generated directly from the PathMe Viewer for any set of pathways, as visualized in b)