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Table 3 Consolidated pathway representations, their similarity indexes, and links to visualize the merged networks in the PathMe Viewer. A detailed analysis with the scripts to replicate the results and comments on the identified overlaps for each of the 21 equivalent pathways is available at

From: PathMe: merging and exploring mechanistic pathway knowledge

KEGG Reactome WikiPathways Pathway Similarity Index
Cell cycle Cell Cycle Cell Cycle 0.70
Toll-like receptor signaling pathway Toll-Like Receptors Cascades Toll-like Receptor Signaling Pathway 0.62
mTOR signaling pathway mTOR signalling Target Of Rapamycin (TOR) Signaling 0.58
Hedgehog signaling pathway Signaling by Hedgehog Hedgehog Signaling Pathway 0.56
Apoptosis Apoptosis Apoptosis 0.43
IL-17 signaling pathway Interleukin-17 signaling IL17 signaling pathway 0.42
PI3K-Akt signaling pathway PI3K/AKT activation PI3K-Akt Signaling Pathway 0.42
Wnt signaling pathway Signaling by WNT Wnt Signaling Pathway 0.41
MAPK signaling pathway MAPK family signaling cascades MAPK Signaling Pathway 0.40
B cell receptor signaling pathway B Cell Receptor Signaling Pathway Signaling by the B Cell Receptor (BCR) 0.37
Pentose phosphate pathway Pentose phosphate pathway (hexose monophosphate shunt) Pentose Phosphate Pathway 0.33
Citrate cycle (TCA cycle) Citric acid cycle (TCA cycle) TCA Cycle 0.33
Synthesis and degradation of ketone bodies Ketone body metabolism Synthesis and Degradation of Ketone Bodies 0.33
Notch signaling pathway Signaling by NOTCH Notch Signaling Pathway 0.29
DNA replication DNA Replication DNA Replication 0.28
Prolactin signaling pathway Prolactin receptor signaling Prolactin receptor signaling 0.28
TGF-beta signaling pathway Signaling by TGF-beta family members TGF-beta Signaling Pathway 0.26
Thyroid hormone synthesis Thyroxine biosynthesis Thyroxine (Thyroid Hormone) Production 0.20
Sphingolipid metabolism Sphingolipid metabolism Sphingolipid Metabolism 0.16
Mismatch repair Mismatch Repair Mismatch repair 0.08
Non-homologous end-joining Nonhomologous End-Joining (NHEJ) Non-homologous end joining 0