Fig. 1
From: Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity
MHC:peptide: TCR recognition. An MHC (brown) presents a peptide (red spheres) to a TCR (light blue: α chain; light green: β chain) (PDB id 2bnr [67], rendered via PyMOL [68]). The TCR interacts with the MHC and peptide through its CDR loops, with the first two CDRs of each TCR chain generally recognizing mainly the MHC and the third the peptide; here the CDR3α and CDR3β are “grabbing” a methionine and tryptophan in the middle of the peptide (inspired by Chen et al. [67])