Fig. 2
From: NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline
Analysis of neoantigens in two colorectal tumors using NeoPredPipe. a Venn diagram of all neoantigens in the five regions of Adenoma 3. b Number of neoantigens in the two samples that are clonal (present in all regions, shown in blue), shared (present in at least two regions, in yellow) or subclonal (present in a single region, red). Separate counts of weak and strong MHC-binding neoantigens (WB and SB, respectively) are also shown. c Distribution of recognition potential values of neoantigens present in Adenoma 3 (green) and Carcinoma 7 (red). The boxplots represent the median and upper and lower 25 percentile. Only neoantigens with recognition potential higher than zero are shown. d Phylogenetic tree reconstructed from all exonic mutations for Adenoma 3 (left) and Carcinoma 7 (right). Pie-charts and the bar-charts represent the number of weak (orange) and strong (red) binder neoantigens assigned to each branch. The size of each circle is proportional to the percentage of total neoantigens on that branch