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Table 4 Comparison of PD versus non-PD individuals. Significant results are shown in bold type. For each gene the most significant result only of all SNV association tests is shown and for each these the rs id is provided. Additionally, the number of SNV association test conducted within each gene is indicated in brackets. No correction is made for testing of six genes nor for testing multiple SNVs within any given gene

From: GenePy - a score for estimating gene pathogenicity in individuals using next-generation sequencing data

Test PD vs non-affected samples LRRK2 PARK7 PINK1 PRKN SNCA VPS35
GenePy 0.178 0.445 0.013 0.983 0.828 0.206
SKAT-O 1 0.557 0.157 0.427 0.712 0.741
Top 5% comparison 0.002 0.107 0.010 0.021 0.347 0.036
Most significant SNV
(# tested)
0.034
rs10878245
(88)
0.081
rs71653621
(6)
0.042
rs148871409
(21)
0.051
rs1801582
(27)
0.433
rs548523899
(7)
0.433
rs168745
(17)