Fig. 7

Flowchart of the proposed model. From the KEGG pathway database, the user selects a cancer pathway and by digital circuit transformation rules, the equivalent circuit of the selected pathway is obtained. By applying simulation rules, drugs or miRNAs are introduced in the circuit as well as gene mutations, according to the explanation given in the “Simulation” section. Looking at the KEGG pathway, we identify pro-apoptotic and proliferative genes. Therefore, the simulation ready circuit is ready. After applying the input test vector, simulation is running thus resulting in the simulation score