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Fig. 8 | BMC Bioinformatics

Fig. 8

From: MiRNA therapeutics based on logic circuits of biological pathways

Fig. 8

A detail of the proposed flowchart. On the left “cloud” component drug databases are explained: Drugs are selected from KEGG drug and DrugBank databases and then filtered by approved or investigational status. In the middle “cloud” component, miRNAs selection is explained: miRNAs are selected from miRTarBase and miRTissue databases: post-filtering occurs as discussed in the “Simulation” section. In the right “cloud” the gene databases are explained: mutations are retrieved from ClinVar and applied to simulation rules as well as information about tumor suppressive or oncogenic role of mutated genes, retrieved from TSG and NCG databases; in order to generate the input test vector, growth factors (retrieved from UniProt), tumor suppressors and oncogenes are identified

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