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Table 1 NSCLC case study. Gene mutations retrieved from ClinVar. Gene name, accession number, mutation, clinical significance and literature references are reported, respectively

From: MiRNA therapeutics based on logic circuits of biological pathways

GeneAccessionMutationClinical significanceRef
EGFRNM_005228.4(EGFR)c.2573T>G (p.Leu858Arg)Pathogenic-drug response([61])
ERBB2NM_001005862.2(ERBB2)c.2223_2234dupATACGTGATGGCPathogenic/Likely pathogenic([62])
  (p.Ala745_Gly746insTyrValMetAla)  
ALKNM_004304.4(ALK)c.3522C>A (p.Phe1174Leu)Pathogenic/Likely pathogenic([63])
PTENNM_000314.6(PTEN)c.697C>T (p.Arg233Ter)Pathogenic([64])
KRASNM_004985.4(KRAS)c.437C>T (p.Ala146Val) ([65])
BRAFNM_004333.5(BRAF)c.1794_1796dup (p.Thr599_Val600insThr)Pathogenic-drug response([66])
PI3KNM_006218.3(PIK3CA)c.3140A>G (p.His1047Arg)Pathogenic/Likely pathogenic([67, 68])
AKT1NM_005163.2(AKT1)c.49G>A (p.Glu17Lys)Pathogenic/Likely pathogenic([69, 70])
MEK/MAP2K1NM_002755.3(MAP2K1)c.167A>C (p.Gln56Pro)Pathogenic([71, 72])
EML4-ALK-p16 chr2:29446394..42552694 inversionPathogenic([73])