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Table 3 NSCLC case study. Effects of drugs, in terms of the score defined in “Simulation” Section, on gene mutations

From: MiRNA therapeutics based on logic circuits of biological pathways

DrugsEGFRERBB2EML4-ALKPTENKRASBRAFPIK3CAAKTMEKEML4-ALK+p16Ranking
Score obtained by a single drug
Everolimus2 → -11 → -23 → 00 → -32 → -1-2 → -21 → -20 → -3-2 → -24 → 1-15
BKM1202 → -11 → -23 → 00 → 02 → -1-2 → -21 → -30 → 0-2 → -24 → 1-10
Alectinib2 → 21 → 13 → -30 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → -3-4
Trametinib2 → 11 → 03 → 20 → 02 → 1-2 → -31 → 00 → 0-2 → -34 → 20
Dabrafenib2 → 11 → 03 → 20 → 02 → 1-2 → -31 → 00 → 0-2 → -24 → 21
Osimertinib2 → -31 → 13 → 30 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 44
Score obtained by the combination of two drugs
Everolimus2 → -11 → -33 → -10 → -32 → -2-2 → -31 → -30 → -3-2 → -34 → -1-23