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Table 3 NSCLC case study. Effects of drugs, in terms of the score defined in “Simulation” Section, on gene mutations

From: MiRNA therapeutics based on logic circuits of biological pathways

Drugs EGFR ERBB2 EML4-ALK PTEN KRAS BRAF PIK3CA AKT MEK EML4-ALK+p16 Ranking
Score obtained by a single drug
Everolimus 2 → -1 1 → -2 3 → 0 0 → -3 2 → -1 -2 → -2 1 → -2 0 → -3 -2 → -2 4 → 1 -15
BKM120 2 → -1 1 → -2 3 → 0 0 → 0 2 → -1 -2 → -2 1 → -3 0 → 0 -2 → -2 4 → 1 -10
Alectinib 2 → 2 1 → 1 3 → -3 0 → 0 2 → 2 -2 → -2 1 → 1 0 → 0 -2 → -2 4 → -3 -4
Trametinib 2 → 1 1 → 0 3 → 2 0 → 0 2 → 1 -2 → -3 1 → 0 0 → 0 -2 → -3 4 → 2 0
Dabrafenib 2 → 1 1 → 0 3 → 2 0 → 0 2 → 1 -2 → -3 1 → 0 0 → 0 -2 → -2 4 → 2 1
Osimertinib 2 → -3 1 → 1 3 → 3 0 → 0 2 → 2 -2 → -2 1 → 1 0 → 0 -2 → -2 4 → 4 4
Score obtained by the combination of two drugs
Everolimus 2 → -1 1 → -3 3 → -1 0 → -3 2 → -2 -2 → -3 1 → -3 0 → -3 -2 → -3 4 → -1 -23