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Table 7 Melanoma case study. Gene mutations retrieved from ClinVar. Gene name, accession number, mutation, clinical significance and literature references are reported, respectively

From: MiRNA therapeutics based on logic circuits of biological pathways

GeneAccessionMutationClinical significanceRef
BRAFNM_004333.4c.1799T>G (p.Val600Gly)Pathogenic([74])
RAF(ARAF)NM_001654.4c.640T>G (p.Ser214Ala)Likely pathogenic([75])
NRASNM_002524.4c.182_183delAAinsGG (p.Gln61Arg)Pathogenic([76])
RAS (KRAS)NM_004985.4c.351A>C (p.Lys117Asn)Pathogenic/Likely pathogenic([75])
AKT1NM_005163.2c.235C>A (p.Gln79Lys)Likely pathogenic([77])
PI3KNM_006218.3c.3140A>T (p.His1047Leu)Pathogenic([78])
MEK/MAP2K1NM_002755.3c.157T>C (p.Phe53Leu)Pathogenic([79])
CDK/CDKN2ANM_000077.4c.148C>T (p.Gln50Ter)Pathogenic([80])