Table 9 Melanoma case study. Effects of drugs, in terms of the score defined in “Simulation” Section, on gene mutations
From: MiRNA therapeutics based on logic circuits of biological pathways
Drugs | BRAF | RAF | NRAS | RAS | AKT | PI3K | MEK | CDK4/6 | Ranking |
|---|---|---|---|---|---|---|---|---|---|
Score obtained by a single drug | |||||||||
Everolimus | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → 0 | -7 |
BKM120 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → 0 | 0 → -1 | -1 → -1 | 0 → 0 | -6 |
Ribociclib | -1 → -1 | -1 → -1 | 0 → 0 | 0 → 0 | 0 → 0 | 0 → 0 | -1 → -1 | 0 → -1 | -4 |
Trametinib | -1 → -1 | -1 → -1 | 0 → 0 | 0 → 0 | 0 → 0 | 0 → 0 | -1 → -1 | 0 → 0 | -3 |
Dabrafenib | -1 → -1 | -1 → -1 | 0 → 0 | 0 → 0 | 0 → 0 | 0 → 0 | -1 → -1 | 0 → 0 | -3 |
Omacetaxine | -1 → -1 | -1 → -1 | 0 → 0 | 0 → 0 | 0 → 0 | 0 → 0 | -1 → -1 | 0 → 0 | -3 |
Score obtained by the combination of two drugs | |||||||||
Everolimus/Ribociclib | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → -1 | -8 |
Everolimus/BKM120 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → 0 | -7 |