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Table 9 Melanoma case study. Effects of drugs, in terms of the score defined in “Simulation” Section, on gene mutations

From: MiRNA therapeutics based on logic circuits of biological pathways

DrugsBRAFRAFNRASRASAKTPI3KMEKCDK4/6Ranking
Score obtained by a single drug
Everolimus-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → 0-7
BKM120-1 → -1-1 → -10 → -10 → -10 → 00 → -1-1 → -10 → 0-6
Ribociclib-1 → -1-1 → -10 → 00 → 00 → 00 → 0-1 → -10 → -1-4
Trametinib-1 → -1-1 → -10 → 00 → 00 → 00 → 0-1 → -10 → 0-3
Dabrafenib-1 → -1-1 → -10 → 00 → 00 → 00 → 0-1 → -10 → 0-3
Omacetaxine-1 → -1-1 → -10 → 00 → 00 → 00 → 0-1 → -10 → 0-3
Score obtained by the combination of two drugs
Everolimus/Ribociclib-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → -1-8
Everolimus/BKM120-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → 0-7