Table 1 Gene sets association with training class labels at iteration 0 or classification at iteration 7. Gene sets associated with p value < 0.1 and FDR < 0.25 in gene set enrichment analysis of the development set (DEV), the internal validation set (INT VAL) and the independent validation set (IND VAL) are marked with “X”

MYC Targets V2

X

X

X

X

X

X

Spermatogenesis

X

X

X

X

X

X

G2M Checkpoint

X

X

X

X

X

X

E2F Targets

X

X

X

X

X

X

Estrogen Response Early

X

X

X

X

X

PI3K AKT MTOR Signaling

X

X

X

X

X

DNA Repair

X

X

X

X

X

Mitotic Spindle

X

X

X

X

X

MTORC1 Signaling

X

X

X

X

X

MYC Targets V1

X

X

X

X

X

Cholesterol Homeostasis

X

X

X

X

UV Response Up

X

X

X

X

Glycolysis

X

X

X

X

Unfolded Protein Response

X

X

X

X

Reactive Oxygen Species Pathway

X

X

X

X

UV Response Down

X

X

X

X

X

Oxidative Phosphorylation

X

X

X

X

Epithelial Mesenchymal Transition

X

X

X

X

Angiogenesis

X

X

X

Myogenesis

X

X

X

Coagulation

X

X

X

TGF beta Signaling

X

X

NOTCH Signaling

X

Interferon gamma Response

X

X

X

Inflammatory Response

X

Allograft Rejection

X

Interferon alpha Response

X

Estrogen Response Late

X