Bayesian model selection for the Drosophila gap gene network

BMC Bioinformatics

Table 1 Specifications for all 6 models evaluated

Models	A6	B7	B7r	C8	D7	D8
Global parameters:
Affinity(logKa)	K	K	K	K	K	K
Cooperativity	C _o	C _o	C _o	C _o	C _o	C _o
Binding Sites	N _s	N _s	N _s	N _s	N _s	N _s
Syn./Decay	α	α	α	α	α	α
Diffusion	D	D	D	D	D	D
Max. conc	50	50	50	50	50	50
Node-specific binding affinities:
Bcd ^A	K	K	K ₃	K ₃	K	K ₃
Bcd ^R	K	K	K	K	K	K
Cad ^A	K	K	K	K	K	K
Hb ^A	K	K	K	K	K	K
Hb ^D	K	K	K	K	K	K
Hb ^R	K ₁	K ₁	K ₁	K ₁	K ₁	K ₁
Gt ^R	K	K	K	K	K	K
Kr ^R	K ₁	K ₂	K ₁	K ₂	K ₂	K ₂
Kni ^R	K	K	K	K	K	K
Tll ^R	K	K	K	K	K	K
Open Parameters:	6	7	7	8	7	8

Models D7 and D8 have an extra edge for the activation of Bicoid by Kruppel. Also shown is the break up of global and node-specific parameters for different models. Hb^D indicates parameter for the dual regulatory action of Hunchback on Kruppel

ISSN: 1471-2105