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Fig. 7 | BMC Bioinformatics

Fig. 7

From: COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining

Fig. 7

COMBO-Mine Flowchart. (1) Results from all four analysis modules, COMBO-C, COMBO-M, COMBO-MF and COMBO-V, are required; (2) The extracted response patterns from (1) are organized into groups with similar behavior. For this grouping, multilevel K-means clustering is currently employed; (3) The smallest non-redundant subset of drugs and/or drug combinations for each group is identified by an exhaustive algorithmic search as shown in Fig. 8. (4) Each group is visualized by the corresponding average temporal profiles as determined by (2) and represented by the smallest non-redundant subset obtained from (3)

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