From: Estimating statistical significance of local protein profile-profile alignments
Input | Evaluation | x | COMER new | COMER new (alt.) | COMER v1.4 | ||
---|---|---|---|---|---|---|---|
ROCx | Z (p-value) | ROCx | Z (p-value) | ROCx | |||
HHblits MSAs | Sensitivity | 6000 | 0.837 | 0.9 (0.350) | 0.836 | 0.6 (0.571) | 0.835 |
PSI-BLAST MSAs | Sensitivity | 6000 | 0.705 | 5.6 (1.7×10−8) | 0.698 | 2.6 (0.009) | 0.690 |
HHblits MSAs | Local | 150 | 0.782 | 0.9 (0.350) | 0.753 | −0.9 (0.352) | 0.768 |
Global | 10000 | 0.456 | 8.6 (<3×10−16) | 0.456 | 7.3 (3.8×10−13) | 0.438 | |
Local (max ext) | 1000 | 0.628 | 9.0 (<3×10−16) | 0.624 | 7.1 (1.7×10−12) | 0.591 | |
Global (max ext) | 1700 | 0.603 | 7.6 (3.9×10−14) | 0.598 | 7.2 (7.7×10−13) | 0.574 | |
PSI-BLAST MSAs | Local | 400 | 0.642 | 1.6 (0.103) | 0.623 | 0.2 (0.874) | 0.621 |
Global | 22000 | 0.330 | 3.7 (2.2×10−4) | 0.334 | 4.9 (1.2×10−6) | 0.321 | |
Local (max ext) | 2500 | 0.496 | 5.3 (1.2×10−7) | 0.499 | 6.3 (2.8×10−10) | 0.477 | |
Global (max ext) | 5000 | 0.471 | 5.1 (3.0×10−7) | 0.474 | 5.6 (2.1×10−8) | 0.457 |