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Fig. 1 | BMC Bioinformatics

Fig. 1

From: A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery

Fig. 1

a An example protein-protein interaction network with three proteins and two protein translation process inputs. The state space representation of the same network demonstrates that the change in state of a protein’s concentration is a function of its current state and an input process. A classic controllability analysis demonstrates that this system is fully controllable and could, therefore, be driven to any possible state change in every protein. b Example application of robust controllability, which determines the robustness of the network after the removal of a protein. c Example application of global controllability which assesses the importance of a protein to all methods of network control

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BMC Bioinformatics

ISSN: 1471-2105

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