Table 1 Identities of the proteins that are drivers in the HIN but not the VIN with the shortest number of paths to an Influenza A viral protein. Degree and betweenness of the proteins of the VIN is provided (with the values from the HIN in parenthesis). Only 45% of these proteins are directly interacting with the viral proteins, demonstrating the cascade effect caused by the inclusion of viral interactions
Entrez ID | Gene Name | Shortest Distance to IAV Protein | Degree | Betweenness |
|---|---|---|---|---|
10658 | CUGBP, Elav-Like Family Member 1 (CELF1) | 1 | 4 (4) | 81 (81) |
1969 | EPH Receptor A2 (EPHA2) | 1 | 14 (13) | 93 (0) |
6733 | SRSF Protein Kinase 2 (SRPK2) | 1 | 6 (2) | 6023 (6023) |
10318 | TNFAIP3 Interacting Protein 1 (TNIP1) | 1 | 7 (7) | 115 (115) |
2997 | Glycogen Synthase 1 (GYS1) | 3 | 4 (4) | 384 (384) |
10949 | Heterogeneous Nuclear Ribonucleoprotein A0 (HNRNPA0) | 2 | 9 (2) | 5 (0) |
64112 | Modulator of Apoptosis 1 (MOAP1) | 1 | 8 (8) | 6942 (6931) |
10419 | Protein Arginine Methyltransferase 5 (PRMT5) | 3 | 26 (17) | 6996 (4743) |
10262 | Splicing Factor 3b Subunit 4 (SF3B4) | 3 | 13 (7) | 82 (44) |
23321 | Tripartite Motif Containing 2 (TRIM2) | 3 | 2 (2) | 15 (15) |
81603 | Tripartite Motif Containing 8 (TRIM8) | 3 | 3 (3) | 0 (0) |