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Table 1 Identities of the proteins that are drivers in the HIN but not the VIN with the shortest number of paths to an Influenza A viral protein. Degree and betweenness of the proteins of the VIN is provided (with the values from the HIN in parenthesis). Only 45% of these proteins are directly interacting with the viral proteins, demonstrating the cascade effect caused by the inclusion of viral interactions

From: A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery

Entrez ID Gene Name Shortest Distance to IAV Protein Degree Betweenness
10658 CUGBP, Elav-Like Family Member 1 (CELF1) 1 4 (4) 81 (81)
1969 EPH Receptor A2 (EPHA2) 1 14 (13) 93 (0)
6733 SRSF Protein Kinase 2 (SRPK2) 1 6 (2) 6023 (6023)
10318 TNFAIP3 Interacting Protein 1 (TNIP1) 1 7 (7) 115 (115)
2997 Glycogen Synthase 1 (GYS1) 3 4 (4) 384 (384)
10949 Heterogeneous Nuclear Ribonucleoprotein A0 (HNRNPA0) 2 9 (2) 5 (0)
64112 Modulator of Apoptosis 1 (MOAP1) 1 8 (8) 6942 (6931)
10419 Protein Arginine Methyltransferase 5 (PRMT5) 3 26 (17) 6996 (4743)
10262 Splicing Factor 3b Subunit 4 (SF3B4) 3 13 (7) 82 (44)
23321 Tripartite Motif Containing 2 (TRIM2) 3 2 (2) 15 (15)
81603 Tripartite Motif Containing 8 (TRIM8) 3 3 (3) 0 (0)