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Table 4 Identities of global Proteins (proteins that shift global classification between the HIN and VIN). All identified proteins are directly interacting with viral proteins. Degree and betweenness of the proteins of the VIN is provided (with the values from the HIN in parenthesis)

From: A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery

Entrez ID Gene Name Shortest Distance to IAV Protein Degree Betweenness
56655 DNA Polymerase Epsilon 4, Accessory Subunit (POLE4) 1 2 (1) 1 (0)
30846 EH Domain Containing 2 (EHD2) 1 3 (1) 1 (0)
1969 EPH Receptor A2 (EPHA2) 1 14 (13) 93 (0)
2665 GDP Dissociation Inhibitor 2 (GDI2) 1 3 (1) 2 (0)
51552 RAB14, Member RAS Oncogene Family (RAB14) 1 2 (1) 1 (0)
2091 Fibrillarin (FBL) 1 9 (4) 19 (0)
10949 Heterogeneous Nuclear Ribonucleoprotein A0 (HNRNPA0) 1 9 (2) 5 (0)
3032 Hydroxyacyl-Coa Dehydrogenase/3-Ketoacyl-Coa Thiolase/Enoyl-Coa Hydratase (Trifunctional Protein), Beta Subunit (HADHB) 1 9 (5) 26 (0)
3419 Isocitrate Dehydrogenase 3 (NAD(+)) Alpha (IDH3A) 1 3 (1) 2 (0)
4191 Malate Dehydrogenase 2 (MDH2) 1 3 (1) 1 (0)
64949 Mitochondrial Ribosomal Protein S26 (MRPS26) 1 2 (1) 0 (0)
9180 Oncostatin M Receptor (OSMR) 1 6 (5) 18 (0)
5052 Peroxiredoxin 1 (PRDX1) 1 11 (4) 44 (0)
5213 Phosphofructokinase, Muscle (PFKM) 1 6 (5) 17 (0)
26227 Phosphoglycerate Dehydrogenase (PHGDH) 1 4 (2) 9 (0)
5817 Poliovirus Receptor (PVR) 1 7 (6) 42 (0)
5686 Proteasome Subunit Alpha 5 (PSMA5) 1 6 (5) 11 (0)
5464 Pyrophosphatase (Inorganic) 1 (PPA1) 1 6 (5) 5 (0)
113174 Serum Amyloid A Like 1 (SAAL1) 1 2 (1) 1 (0)
6745 Signal Sequence Receptor Subunit 1 (SSR1) 1 4 (2) 12 (0)
7037 Transferrin Receptor (TFRC) 1 11 (8) 164 (0)
8834 Transmembrane Protein 11 (TMEM11) 1 4 (3) 20 (0)
30000 Transportin 2 (TNPO2) 1 2 (1) 1 (0)
7407 Valyl-Trna Synthetase (VARS) 1 3 (1) 0 (0)
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