Skip to main content

Table 4 Identities of global Proteins (proteins that shift global classification between the HIN and VIN). All identified proteins are directly interacting with viral proteins. Degree and betweenness of the proteins of the VIN is provided (with the values from the HIN in parenthesis)

From: A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery

Entrez ID

Gene Name

Shortest Distance to IAV Protein

Degree

Betweenness

56655

DNA Polymerase Epsilon 4, Accessory Subunit (POLE4)

1

2 (1)

1 (0)

30846

EH Domain Containing 2 (EHD2)

1

3 (1)

1 (0)

1969

EPH Receptor A2 (EPHA2)

1

14 (13)

93 (0)

2665

GDP Dissociation Inhibitor 2 (GDI2)

1

3 (1)

2 (0)

51552

RAB14, Member RAS Oncogene Family (RAB14)

1

2 (1)

1 (0)

2091

Fibrillarin (FBL)

1

9 (4)

19 (0)

10949

Heterogeneous Nuclear Ribonucleoprotein A0 (HNRNPA0)

1

9 (2)

5 (0)

3032

Hydroxyacyl-Coa Dehydrogenase/3-Ketoacyl-Coa Thiolase/Enoyl-Coa Hydratase (Trifunctional Protein), Beta Subunit (HADHB)

1

9 (5)

26 (0)

3419

Isocitrate Dehydrogenase 3 (NAD(+)) Alpha (IDH3A)

1

3 (1)

2 (0)

4191

Malate Dehydrogenase 2 (MDH2)

1

3 (1)

1 (0)

64949

Mitochondrial Ribosomal Protein S26 (MRPS26)

1

2 (1)

0 (0)

9180

Oncostatin M Receptor (OSMR)

1

6 (5)

18 (0)

5052

Peroxiredoxin 1 (PRDX1)

1

11 (4)

44 (0)

5213

Phosphofructokinase, Muscle (PFKM)

1

6 (5)

17 (0)

26227

Phosphoglycerate Dehydrogenase (PHGDH)

1

4 (2)

9 (0)

5817

Poliovirus Receptor (PVR)

1

7 (6)

42 (0)

5686

Proteasome Subunit Alpha 5 (PSMA5)

1

6 (5)

11 (0)

5464

Pyrophosphatase (Inorganic) 1 (PPA1)

1

6 (5)

5 (0)

113174

Serum Amyloid A Like 1 (SAAL1)

1

2 (1)

1 (0)

6745

Signal Sequence Receptor Subunit 1 (SSR1)

1

4 (2)

12 (0)

7037

Transferrin Receptor (TFRC)

1

11 (8)

164 (0)

8834

Transmembrane Protein 11 (TMEM11)

1

4 (3)

20 (0)

30000

Transportin 2 (TNPO2)

1

2 (1)

1 (0)

7407

Valyl-Trna Synthetase (VARS)

1

3 (1)

0 (0)