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Fig. 1 | BMC Bioinformatics

Fig. 1

From: In silico analysis of missense mutations in exons 1–5 of the F9 gene that cause hemophilia B

Fig. 1

Formulas for combined predictions. (1 – SIFT), as SIFT scores are inverse to PolyPhen-2 scores, they were scaled by subtracting from 1. PolyPhen, score obtained from PolyPhen-2 HumDiv. (SNAP2/100)2, SNAP2 scores may be positive and negative percentages, they were scaled to PolyPhen-2 scores by dividing by 100 and squaring. MutationAssessor, scores range from 4 to − 2. Mutations scoring below 1.9 are considered benign, and so are coded as 1. Predicted values were log-transformed at base 5 to obtain values between 0 and 1. PANTHER and PROVEAN, predictions are categorized as deleterious or benign, and are coded 1 and 0 respectively. n, number of programs used in combined analysis. In the functions wgP6 and wgP4, n is substituted by the weight for each program. In B and C, predicted values in the numerator are multiplied by the weight

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