Table 2 In silico analysis of 215 single nucleotide polymorphisms at F9 exons 1–5
From: In silico analysis of missense mutations in exons 1–5 of the F9 gene that cause hemophilia B
Program | Variants predicted as deleterious (%) | Variants predicted as benign (%) | Accuracy | Weighte |
|---|---|---|---|---|
SIFT | 194 (90.2) | 21 (9.8) | 90.2 | 1 |
PolyPhen-2 HumDiv | 189 (87.9) | 26 (12.1) | 87.9 | 0.974 |
PolyPhen-2 HumVar | 179 (83.3) | 36 (16.7) | ||
SNAP2 | 184 (58.6) | 31 (14.4) | 85.6 | 0.924 |
MutationAssessora | 188 (87.4) | 27 (12.6) | 87.4 | 0.896 |
PANTHER | 184 (85.6) | 31 (14.4) | 85.6 | 0.850 |
PROVEAN | 176 (81.9) | 39 (18.1) | 81.9 | 0.772 |
gP b | 184 (85.6) | 31 (14.4) | ||
wgP6c | 184 (85.6) | 31 (14.4) | ||
wgP4d | 187 (87.0) | 28 (13.0) |