In silico analysis of missense mutations in exons 1–5 of the F9 gene that cause hemophilia B

BMC Bioinformatics

Table 3 Association between clinical severity and in silico analysis of single nucleotide polymorphisms^c

	Leader sequence^d + Light chain^e			Gla Domain			EGF-2 Domain			Light chain^e
	χ²	P (two-tailed)^a	P (two-tailed)^b	χ²	P (two-tailed)^a	P (two-tailed)^b	χ²	P (two-tailed)^a	P (two-tailed)^b	χ²	P (two-tailed)^a	P (two-tailed)^b
SIFT	6.610^a	0.010	0.016	14.571^a	0.000	0.002	5.296^a	0.021	0.053	14.734^a	0.000	0.000
PolyPhen-2 HumDiv	4.964^a	0.026	0.049	10.767^a	0.001	0.010	12.002^a	0.001	0.005	10.339^a	0.001	0.003
PolyPhen-2 HumVar	1.755^a	0.185	0.206	0.129^a	0.719	1.000	11.703^a	0.001	0.004	3.401^a	0.065	0.081
SNAP2	3.854^a	0.050	0.070	10.767^a	0.001	0.010	15.713^a	0.000	0.002	7.927^a	0.005	0.010
Mutation Assessor	12.300^a	0.000	0.001	6.684^a	0.010	0.034	5.296^a	0.021	0.053	15.903	0.000	0.000
PANTHER	0.026^a	0.872	0.826				0.080^a	0.778	1.000	1.317^a	0.251	0.272
PROVEAN	0.324^a	0.569	0.545	3.896^a	0.048	0.070	6.930^a	0.008	0.018	1.809^a	0.179	0.213
gP	1.128^a	0.288	0.367	10.767^a	0.001	0.010	4.749^a	0.029	0.051	3.626^a	0.057	0.084
wgP6	1.128^a	0.288	0.367	10.767^a	0.001	0.010	4.749^a	0.029	0.051	3.626^a	0.057	0.084
wgP4	5.745^a	0.017	0.032	10.767^a	0.001	0.010	7.318^a	0.007	0.029	9.272^a	0.002	0.008

ISSN: 1471-2105