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Fig. 18 | BMC Bioinformatics

Fig. 18

From: AutoCryoPicker: an unsupervised learning approach for fully automated single particle picking in Cryo-EM images

Fig. 18

Evaluation of particle picking using EMAN2 and AutoCryoPicker. a Apoferritin cryo-EM image with top-view particle shapes only. b The ground truth (manually particle picking labels) of the first Apoferritin cryo-EM image where each particle is marked by a yellow circle on top of each particle. c The particle picking results of the first Apoferritin image using EMAN2. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN). d The particle picking results of the first Apoferritin cryo-EM image using AutoCryoPicker. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN); orange, False Positive (FP). e The second original Apoferritin cryo-EM image with top-view particle shapes only. f The ground truth (manually particle picking labels) of the second Apoferritin cryo-EM image where each particle is marked by a yellow circle on top of each particle. g The particle picking results of the second Apoferritin cryo-EM image using EMAN2. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN); orange, False Positive (FP). h The particle picking results of the second Apoferritin cryo-EM image using AutoCryoPicker. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN); orange, False Positive (FP). i The first original KLH cryo-EM image. (j) The ground truth (manually particle picking labels) of the first KLH cryo-EM image where each particle is marked by a yellow circle on top of each particle. k The particle picking results of the first KLH image using EMAN2. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN). l The particle picking results of the first KLH cryo-EM image using AutoCryoPicker. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN). m The second original KLH cryo-EM image which has top-view particle shapes only. n The ground truth (manually particle picking labels) of the second KLH cryo-EM image where each particle is marked by a yellow circle on top of each particle. o The particle picking results of the second KLH cryo-EM image using EMAN2. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN). p The particle picking results of the second KLH cryo-EM image using AutoCryoPicker. The particles are labeled as follows: Green, True Positive (TP); red, False Negative (FN)

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