Fig. 3

Jackknife curves of RWHN and ten other existing centrality methods. The x-axis represents the proteins in PPI network ranked by RWHN and ten other methods, ranked from left to right as strongest to weakest prediction of essentiality. The Y-axis is the cumulative count of essential proteins encountered moving left to right through the ranked. The areas under the curve for RWHN and the ten other methods are used to compare their prediction performance. In addition, the 10 random assortments are also plotted for comparison. a shows the comparison results of RWHN, DC, IC, SC and DC. b shows the comparison results of RWHN, BC, CC and NC. c shows the comparison results of RWHN and other four methods: PeC, CoEWC, POEM and ION