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Table 4 List of the kinetic parameters of the EGFR-IGF1R model and their corresponding nominal values

From: CRA toolbox: software package for conditional robustness analysis of cancer systems biology models in MATLAB

Parameter Name Value
p 1 γ EGFR 0.02
p 2 γ IGF1R 0.02
p 3 k d PIK3 0.005
p 4 k p90Rsk-Erk 0.0213697
p 5 K M p90Rsk-Erk 763523
p 6 k SOS-EGFR 694.731
p 7 KM SOS-EGFR 6086070
p 8 k Ras-SOS 32.344
p 9 KM Ras-SOS 35954.3
p 10 k Erk-MEK 9.85367
p 11 KM Erk-MEK 1007340
p 12 k DSOS-p90Rsk 161197
p 13 KM DSOS-p90Rsk 896896
p 14 k SOS-IGFR 500
p 15 KM SOS-IGFR 1000000
p 16 k PIK3-IGF1R 10.6737
p 17 KM PIK3-IGF1R 184912
p 18 k PIK3-EGFR 10.6737
p 19 KM PIK3-EGFR 184912
p 20 k Akt-PIK3 0.0566279
p 21 KM Akt-PIK3 653951
p 22 kd Akt 0.005
p 23 k Erk-PP2A 9.85367
p 24 KM Erk-PP2A 1007340
p 25 k PIK3-Ras 0.0771067
p 26 KM PIK3-Ras 272056
p 27 k Raf-Ras 0.884096
p 28 KM Raf-Ras 62464.6
p 29 k Raf-MEK 185.759
p 30 KM Raf-MEK 4768350
p 31 k Raf-Akt 15.1212
p 32 KM Raf-Akt 119355
p 33 k Ras-RasGab 1509.36
p 34 KM Ras-RasGab 1432410
p 35 k MEK-PP2A 2.83243
p 36 KM MEK-PP2A 518753
p 37 k Raf-RafPP 0.126329
p 38 KM Raf-RafPP 1061.71
p 39 kd p90Rsk 0.005