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Table 3 Phenotype prediction methods used to obtain the performance metrics featured in this work

From: Comparison of pathway analysis and constraint-based methods for cell factory design

Method Objective function Constraints Productivity metrics
pFBA Min (|v|) subject to Max (vbiomass) Environmental conditions Maximum cell growth = vbiomass
Production rate = vproduct
Biomass-product coupled yield: \( BPCY(v)=\frac{v_{biomass}\ast {v}_{product}}{v_{substrate}} \)
FVA Min (vproduct) Environmental conditions vbiomassx Max (vbiomass) Production robustness at x % growth = Min (vproduct)