Skip to main content

Advertisement

Fig. 4 | BMC Bioinformatics

Fig. 4

From: Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line

Fig. 4

Graphical representation of EGF regulation by RNAi treatment. Each differentially expressed gene can be grouped into exactly one of the following eight gene groups A - H. These eight gene groups (A - H) contain all possible theoretical models of regulation of a gene, after EGF addition in combination with the three RNAi treatments. Subfigure (a) corresponds to the control experiment without RNAi treatment, subfigure (b) corresponds to RNAi treatment with siRNAI, and subfigure (c) corresponds to RNAi treatment with siRNAALL. Red crosses indicate the down-regulation of EGFR by RNAi treatment with siRNAI (b) or siRNAALL (c). The change of gene expression (up or down) by EGF treatment is indicated by 1 and no change by 0, i.e., all genes except those of gene group A should be differentially expressed in the control experiment (a), all genes except those of gene groups A and D should be differentially expressed in experiment (b), and all genes except those of gene groups A, C, D, and H should be differentially expressed in experiment (c)

Back to article page