Fig. 3
From: Determination of growth-coupling strategies and their underlying principles
Ethanol production envelopes of GC strain designs identified by gcOpt in comparison to designs taken from literature. Maximal intervention sizes between one and five reaction deletions were used (a-c) and compared to several methods reported in the literature (d) (MMF strategy from [4], all others from [20]). Black lines denote the production envelopes of the wild-type. The vertical black dashed lines mark the chosen fixed growth rates μfix for the respective computations (0.01 h−1 (a), 0.1 h−1 (b) and 0.25 h−1 (c)). The maximal glucose uptake rate was constrained to 12 mmol g−1 h−1 for all respective simulations